An important role of endothelial hairy-related transcription factors in mouse vascular development.

• Material Type: 博士論文
• ISSN: 1526-954X
• Title: An important role of endothelial hairy-related transcription factors in mouse vascular development.
• Volume: 52 11
• Author/Editor: Morioka, Takashi; Sakabe, Masahide; Ioka, Tomoko; Iguchi, Tomoko; Mizuta, Ken; Hattammaru, Miwa; Sakai, Chihiro; Itoh, Munehiro; Sato, Genki E.; Hashimoto, Aya; Fujita, Masahide; Okumura, Kazuki; Araki, Mutsumi; Xin, Mei; Pedersen, Roger A.; Utset, Manuel F.; Kimura, Hiroshi; Nakagawa, Osamu
• Author Heading: Morioka, Takashi; Sakabe, Masahide; Ioka, Tomoko; Iguchi, Tomoko; Mizuta, Ken; Hattammaru, Miwa; Sakai, Chihiro; Itoh, Munehiro; Sato, Genki E.; Hashimoto, Aya; Fujita, Masahide; Okumura, Kazuki; Araki, Mutsumi; Xin, Mei; Pedersen, Roger A.; Utset, Manuel F.; Kimura, Hiroshi; Nakagawa, Osamu
• Publication, Distribution, etc.: Wiley
• Publication Date: 2014-11; 52 11
• Publication Date (W3CDTF): 2014-11
• Alternative Title: 内皮細胞におけるHrt転写調節因子の血管形態形成に対する意義
• Periodical title: Genesis
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-03-16
• Date Granted (W3CDTF): 2015-03-16
• Dissertation Number: 乙第1352号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1352号
• Text Language Code: eng
• Subject Heading: mouse embryo; vascular morphogenesis; Hrt/Hey; Robo4; Src family kinases
• Target Audience: 一般
• Note (General): type:Article; The Hairy-related transcription factor family of Notch- and ALK1-downstream transcriptional repressors, called Hrt/Hey/Hesr/Chf/Herp/Gridlock, has complementary and indispensable functions for vascular development. While mouse embryos null for either Hrt1/Hey1 or Hrt2/Hey2 did not show early vascular phenotypes, Hrt1/Hey1; Hrt2/Hey2 double null mice (H1ko/H2ko) showed embryonic lethality with severe impairment of vascular morphogenesis. It remained unclear, however, whether Hrt/Hey functions are required in endothelial cells or vascular smooth muscle cells. In this study, we demonstrate that mice with endothelial-specific deletion of Hrt2/Hey2 combined with global Hrt1/Hey1 deletion (H1ko/H2eko) show abnormal vascular morphogenesis and embryonic lethality. Their defects were characterized by the failure of vascular network formation in the yolk sac, abnormalities of embryonic vascular structures and impaired smooth muscle cell recruitment, and were virtually identical to the H1ko/H2ko phenotypes. Among signaling molecules implicated in vascular development, Robo4 expression was significantly increased and activation of Src family kinases was suppressed in endothelial cells of H1ko/H2eko embryos. The present study indicates an important role of Hrt1/Hey1 and Hrt2/Hey2 in endothelial cells during early vascular development, and further suggests involvement of Robo4 and Src family kinases in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.; 博士（医学）・乙第1352号・平成27年3月16日; © 2014 Wiley Periodicals, Inc.; 発行元が定める登録猶予期間終了の後、本文を登録予定（2015.11）; identifier:Genesis Vol.52 No.11 p.897-906; identifier:1526954X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2969; identifier:Genesis, 52(11): 897-906
• DOI: info:doi/10.1002/dvg.22825; https://doi.org/info:doi/10.1002/dvg.22825
• Persistent ID (NDL): info:ndljp/pid/9577605; https://dl.ndl.go.jp/pid/9577605
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-01-05T14:58:43+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2969
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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