Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy

• Material Type: 博士論文
• Title: Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy
• Author/Editor: Saida, Yu
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2015-09-24
• Publication Date (W3CDTF): 2015-09-24
• Alternative Title: Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy; 抗癌剤を用いたリンパ球除去後の抗腫瘍免疫における、抗癌剤耐性エフェクターおよび制御性T cellsの重要な役割
• Degree grantor/type: 新潟大学
• Date Granted: 2015-09-24
• Date Granted (W3CDTF): 2015-09-24
• Dissertation Number: 甲第4064号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4064号
• Text Language Code: eng
• Note (General): Antitumor immunity is augmented by cytotoxic lymphodepletion therapies. Adoptively transferred naive and effector T cells proliferate extensively and show enhanced antitumor effects in lymphopenic recipients. Although the impact of lymphodepletion on transferred donor T cells has been well evaluated, its influence on recipient T cells is largely unknown. The current study demonstrates that both regulatory T cells (Tregs) and effector CD8^+ T cells from lymphopenic recipients play critical roles in the development of antitumor immunity after lymphodepletion. Cyclophosphamide (CPA) treatment depleted lymphocytes more efficiently than other cytotoxic agents; however, the percentage of CD4^+CD25^+ Forkhead box P3^+ Tregs was significantly increased in CPA-treated lymphopenic mice. Depletion of these chemoresistant Tregs following CPA treatment and transfer of naive CD4^+ T cells augmented the antitumor immunity and significantly suppressed tumor progression. Further analyses revealed that recipient CD8^+ T cells were responsible for this augmentation. Using Rag2^<-/-> mice or depletion of recipient CD8^+ T cells after CPA treatment abrogated the augmentation of antitumor effects in CPA-treated reconstituted mice. The transfer of donor CD4^+ T cells enhanced the proliferation of CD8^+ T cells and the priming of tumor-specific CD8^+ T cells originating from the lymphopenic recipients. These results highlight the importance of the recipient cells surviving cytotoxic regimens in cancer immunotherapies.; 学位の種類: 博士（医学）. 報告番号: 甲第4064号. 学位記番号: 新大院博（医）甲第653号. 学位授与年月日: 平成27年9月24日; The Journal of Immunology. 2015, 195(2), 726-735.; 新大院博（医）甲第653号
• DOI: info:doi/10.4049/jimmunol.1401468; https://doi.org/info:doi/10.4049/jimmunol.1401468
• Persistent ID (NDL): info:ndljp/pid/9577845; https://dl.ndl.go.jp/pid/9577845
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-01-05T14:58:43+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://hdl.handle.net/10191/35556
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp