Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan

• Material Type: 博士論文
• Title: Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan
• Author/Editor: Sawano, Takeyuki
• Author Heading: Sawano, Takeyuki
• Publication Date: 2015-09-30
• Publication Date (W3CDTF): 2015-09-30
• Alternative Title: Irinotecan投与によるラット肝の脂肪化誘発とそれに先行する脂肪酸合成酵素陽性細胞の出現; Irinotecan トウヨ ニヨル ラットカン ノ シボウカ ユウハツ ト ソレニ センコウ スル シボウサン ゴウセイ コウソ ヨウセイ サイボウ ノ シュツゲン
• Degree grantor/type: 弘前大学
• Date Granted: 2015-09-30
• Date Granted (W3CDTF): 2015-09-30
• Dissertation Number: 甲第1902号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第1902号
• Text Language Code: eng
• Subject Heading: fatty acid synthase; liver progenitor cell; Kupffer cell; chemotherapy-associated steatohepatitis; irinotecan; 医学
• NDC: 491.6
• Target Audience: 一般
• Note (General): type:Thesis; Using a rat model, I investigated factors contributing to the pathogenesis of irinotecan-associated fatty liver disease. Male Sprague-Dawley rats were administered 200 mg/kg irinotecan by intraperitoneal injection on days 1-4, but not on days 5-7. This schedule was repeated 3 times. Rats were sacrificed 4, 18 and 25 days after the last injection, and liver steatosis was evaluated by hematoxylin and eosin (H&E) staining, microarray analysis and immunohistochemistry. Panacinar intrahepatocyte vacuoles were absent on days 4 and 25, but present on day 18, and this alteration was more prominent around the bile ducts than the central veins. Microarray analysis showed that the expression of genes involved in the synthesis of cholesterol and fatty acids was upregulated on day 4. Immunohistochemistry detected fatty acid synthase (Fasn)-strongly positive hepatocytes as well as the activation of liver progenitor cells on day 4, whereas intracellular vacuoles were evident in carbonic anhydrase 3 (CA3)-positive hepatocytes on day 18. Thus, irinotecan-induced liver steatosis was preceded by Fasn-strongly-positive hepatocytes and liver progenitor cell activation. The magnitude of the decrease in the number of Fasn-strongly positive hepatocytes between days 4 and 18 was similar to that of the increase in the number of CA3-positive hepatocytes accompanying vacuoles.; 掲載誌Oncology reports, 33(5), p.2151-2160, 2015https://www.spandidos-publications.com/or/33/5/2151DOI: 10.3892/or.2015.3814
• Persistent ID (NDL): info:ndljp/pid/9968960; https://dl.ndl.go.jp/pid/9968960
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-05-01T16:38:40+09:00
• Date Created (W3CDTF): 2018-03-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10129/5663
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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