Endogenous neuropeptide S tone influences sleep–wake rhythm in rats

• Material Type: 博士論文
• Title: Endogenous neuropeptide S tone influences sleep–wake rhythm in rats
• Author/Editor: Oishi, Masafumi
• Author Heading: Oishi, Masafumi
• Publication Date: 2015-09-30
• Publication Date (W3CDTF): 2015-09-30
• Alternative Title: 内因性神経ペプチドSがラットにおける睡眠覚醒リズムに影響を与える; ナイインセイ シンケイ ペプチド S ガ ラット ニオケル スイミン カクセイ リズム ニ エイキョウ オ アタエル
• Degree grantor/type: 弘前大学
• Date Granted: 2015-09-30
• Date Granted (W3CDTF): 2015-09-30
• Dissertation Number: 甲第1904号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第1904号
• Text Language Code: eng
• Subject Heading: 基礎医学
• NDC: 491.37
• Target Audience: 一般
• Note (General): type:Thesis; Neuropeptide S (NPS) is an endogenous peptide that exerts wakefulness promoting, analgesic, and anxiolytic effects when administered exogenously. However, it remains to be determined if endogenous NPS tone is involved in the control of the diurnal sleep–wake cycle, or spontanous behavior.In this study, we examined the effects of the NPS receptor antagonist [D-Cys(tBu)5]NPS (2 and 20 nmol, icv) on physiological sleep and spontaneous locomotor behavior. The higher dose of [D-Cys(tBu)5]NPS decreased the amount of time spent in wakefulness [control 782.5 ± 25.5 min, treatment 751.7 ± 28.1 min; p < 0.05] and increased the time spent in NREMS [control 572.6 ± 17.2 min, treatment 600.2 ± 26.1 min; p < 0.05]. There was no statistically significant difference in time spent in REMS. There were no behavioral changes including abnormal gross motor behavior in response to [D-Cys(tBu)5]NPS administration. Collectively these data suggest an involvement of the endogenous NPS/NPS receptor system in physiological sleep architecture.; 掲載誌Neuroscience Letters, 381, 2014, P.94-97doi:10.1016/j.neulet.2014.08.031
• Persistent ID (NDL): info:ndljp/pid/9968962; https://dl.ndl.go.jp/pid/9968962
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-05-01T16:38:40+09:00
• Date Created (W3CDTF): 2018-03-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10129/5665
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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