Increases in plasma Aß40 levels and the Aß40/42 ratio in patients with Diabetes Mellitus and dementia

• Material Type: 博士論文
• Title: Increases in plasma Aß40 levels and the Aß40/42 ratio in patients with Diabetes Mellitus and dementia
• Author/Editor: Ueno, Yaeko
• Author Heading: Ueno, Yaeko
• Publication Date: 2015-09-30
• Publication Date (W3CDTF): 2015-09-30
• Alternative Title: 糖尿病および認知症における血漿アミロイドβ４０および４０/４２比の上昇; トウニョウビョウ オヨビ ニンチショウ ニオケル ケッショウ アミロイドβ40 オヨビ 40/42 ヒノジョウショウ
• Degree grantor/type: 弘前大学
• Date Granted: 2015-09-30
• Date Granted (W3CDTF): 2015-09-30
• Dissertation Number: 甲第1905号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第1905号
• Text Language Code: eng
• Subject Heading: Dementia; Diabetes mellitus; HbA1c; Plasma Aß40; Plasma Aß40/42ratio; 基礎医学
• NDC: 491.32
• Target Audience: 一般
• Note (General): type:Thesis; Aim: The plasma Aß40/42 ratio is a possible biomarker for the onset of Alzheimer’s disease (AD). We here measured plasma Aß40 and Aß42 levels in patients with diabetes mellitus (DM) and dementia in order to clarify the relationship between DMand AD. Methods: Fifty-three patients, including 33 patients with DM and 25 patients with dementia, were assessed using the Mini-mental state examination (MMSE) and brain MRI, plasma Aß40 and Aß42, blood sugar levels, and HbA1c % were measured, and the genotype of apolipoprotein E was determined. Plasma Aß levels and blood sugar levels were measured in 16 out of 53 patients, following fasting and 2 hours after breakfast. Results: Plasma Aβ40 levels and the Aß40/42 ratio were increased in the DM with dementia group (p<0.01, p<0.001), while HbA1c % correlated with the Aß40/42 ratio inthe non-dementia group. MMSE scores were also associated with the plasma Aß40/42 ratio and Aß40 levels in the non-dementia group, independent of the presence of ApoEε4. We did not observed significant direct responses of plasma Aß protains to an increase in blood sugar levels. Conclusion: These results suggest that plasma Aß metabolism are closely related chronic hyperglycemia before the onset of dementia.; 掲載誌弘前医学, 66(2-4), 2016, p.110-119
• Persistent ID (NDL): info:ndljp/pid/9968963; https://dl.ndl.go.jp/pid/9968963
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-05-01T16:38:40+09:00
• Date Created (W3CDTF): 2018-03-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10129/5666
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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