Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers

• Material Type: 博士論文
• Title: Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
• Volume: 2015 11
• Author/Editor: Ishioka, Masamichi
• Author Heading: Ishioka, Masamichi
• Publication, Distribution, etc.: Dove Press Ltd
• Publication Date: 2015-09-30
• Publication Date (W3CDTF): 2015-09-30
• Alternative Title: 抗精神病薬投与中の高プロラクチン血症と凝固因子の関係; コウ セイシンビョウ ヤク トウヨ チュウ ノ コウ プロラクチン ケッショウ ト ギョウコ インシ ノ カンケイ
• Periodical title: Neuropsychiatric Disease and Treatment
• Degree grantor/type: 弘前大学
• Date Granted: 2015-09-30
• Date Granted (W3CDTF): 2015-09-30
• Dissertation Number: 甲第1907号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第1907号
• Text Language Code: eng
• Subject Heading: prolactin; antipsychotics; venous thromboembolism; 基礎医学
• NDC: 491.5
• Target Audience: 一般
• Note (General): type:Thesis; Objective: The strong association between psychiatric patients who receive antipsychotics and the incidence of venous thromboembolism (VTE) is known. Although previous reports suggest that hyperprolactinemia often increases markers of activated coagulation, few studies have examined the direct relationship between the prolactin level elevated by antipsychotics and activated markers of activated coagulation. Method: The participants included 182 patients with schizophrenia (male =89, female =93) who received antipsychotic treatments for at least 3 months. Markers of VTE (D-dimer, fibrin/fibrinogen degradation products, and thrombin–antithrombin complex) and serum prolactin concentrations were measured. Results: Prolactin levels were significantly correlated with the logarithmic transformation of the D-dimer (r=0.320, P=0.002) and fibrin/fibrinogen degradation product levels (r=0.236, P=0.026) but not of the thrombin–antithrombin complex level (r=0.117, ns) among men. However, no correlations were found between the VTE markers and prolactin levels among women. These results were confirmed using multiple regression analyses that included demographic factors and antipsychotic dosages. Conclusion: The current study indicates that hyperprolactinemia is associated with an increase in markers of activated coagulation among men receiving antipsychotics. This finding clinically implies that monitoring and modulating prolactin levels among men are important to decrease the risk of VTE.; 掲載誌Neuropsychiatric Disease and Treatment, 11, 2015, p.477-484DOI http://dx.doi.org/10.2147/NDT.S75176
• DOI: info:doi/10.2147/NDT.S75176; https://doi.org/info:doi/10.2147/NDT.S75176
• Persistent ID (NDL): info:ndljp/pid/9968965; https://dl.ndl.go.jp/pid/9968965
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-05-01T16:38:40+09:00
• Date Created (W3CDTF): 2018-03-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10129/5668
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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