Suppression of Starvation-Induced Autophagy by Recombinant Toxic Shock Syndrome Toxin-1 in Epithelial Cells

• Material Type: 博士論文
• Title: Suppression of Starvation-Induced Autophagy by Recombinant Toxic Shock Syndrome Toxin-1 in Epithelial Cells
• Author/Editor: Asano, Krisana
• Author Heading: Asano, Krisana
• Publication Date: 2015-09-30
• Publication Date (W3CDTF): 2015-09-30
• Alternative Title: 遺伝子組換え毒素性ショック症候群毒素-1による上皮細胞の飢餓誘導オートファジーの抑制; イデンシ クミカエ ドクソセイ ショック ショウコウグン ドクソ-1 ニヨル ジョウヒ サイボウ ノ キガ ユウドウ オートファジー ノ ヨクセイ
• Degree grantor/type: 弘前大学
• Date Granted: 2015-09-30
• Date Granted (W3CDTF): 2015-09-30
• Dissertation Number: 乙第883号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第883号
• Text Language Code: eng
• Subject Heading: 基礎医学
• NDC: 491.6
• Target Audience: 一般
• Note (General): type:Thesis; Toxic shock syndrome toxin-1 (TSST-1), a superantigen produced from Staphylococcus aureus, has been reported to bind directly to unknown receptor(s) and penetrate into non-immune cells but its function is unclear. In this study, we demonstrated that recombinant TSST-1 suppresses autophagosomal accumulation in the autophagic-induced HeLa 229 cells. This suppression is shared by a superantigenic-deficient mutant of TSST-1 but not by staphylococcal enterotoxins, suggesting that autophagic suppression of TSST-1 is superantigenic-independent. Furthermore, we showed that TSST-1-producing S. aureus suppresses autophagy in the response of infected cells. Our data provides a novel function of TSST-1 in autophagic suppression which may contribute in staphylococcal persistence in host cells.; 掲載誌PLoS ONE, November 17, 2014http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0113018; 掲載誌PLOS One, 2014http://dx.doi.org/10.1371/journal.pone.0113018
• Persistent ID (NDL): info:ndljp/pid/9968966; https://dl.ndl.go.jp/pid/9968966
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-05-01T16:38:40+09:00
• Date Created (W3CDTF): 2018-03-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10129/5669
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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