Selective induction of antimicrobial peptides from keratinocytes by staphylococcal bacteria.

• Material Type: 博士論文
• ISSN: 0882-4010
• Title: Selective induction of antimicrobial peptides from keratinocytes by staphylococcal bacteria.
• Volume: 56
• Author/Editor: Ommori, Rie; Ouji, Noriko; Mizuno, Fumiko; Kita, Eiji; Ikada, Yoshito; Asada, Hideo
• Author Heading: Ommori, Rie; Ouji, Noriko; Mizuno, Fumiko; Kita, Eiji; Ikada, Yoshito; Asada, Hideo
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2013-03; 56
• Publication Date (W3CDTF): 2013-03
• Alternative Title: ブドウ球菌の表皮ケラチノサイトからの選択的抗菌ペプチドの誘導
• Periodical title: Microbial pathogenesis
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2016-03-15
• Date Granted (W3CDTF): 2016-03-15
• Dissertation Number: 甲第643号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第643号
• Text Language Code: eng
• Subject Heading: Keratinocytes; Human β-defensin; Staphylococcus aureus; Staphylococcus epidermidis; Toll-like receptor 2
• Target Audience: 一般
• Note (General): type:Thesis; Staphylococcus aureus (S. aureus) is one of the most clinically important inflammation-inducing pathogens, while Staphylococcus epidermidis (S. epidermidis) is nonpathogenic and hardly causes inflammation on skin. β-defensins, antimicrobial peptides, are secreted from keratinocytes constitutively or upon induction by various microorganisms. However, the difference between S. aureus and S. epidermidis is still unclear in terms of their influences on the production of β-defensins. In this study, we focused on the influences of S. aureus and S. epidermidis on the keratinocyte innate immune response. Pathogenic S. aureus mainly induced human β-defensin (hBD) 1 and hBD3, but not hBD2, and nonpathogenic S. epidermidis mainly induced hBD2 from human keratinocytes. Molecular weight fractions of >10 kDa prepared from S. aureus supernatants induced the production of hBD1 and hBD3. On the other hand, molecular weight fraction of >100 kDa prepared from S. epidermidis supernatants induced the production of hBD2.Furthermore, the secreted products of S. epidermidis used the toll-like receptor (TLR) 2 pathway in the induction of hBD2 production. The secreted products of S. aureus and S. epidermidis differentially induced subtypes of hBD through different receptors, which may be associated with the difference in virulence between these two bacteria.; 博士（医学）・甲第643号・平成28年3月15日; Copyright © 2012 Elsevier Ltd. All rights reserved.; identifier:Microbial pathogenesis Vol.56 p.35-39(2013.03); identifier:08824010; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3170; identifier:Microbial pathogenesis, 56: 35-39
• DOI: info:doi/10.1016/j.micpath.2012.11.005; https://doi.org/info:doi/10.1016/j.micpath.2012.11.005
• Persistent ID (NDL): info:ndljp/pid/9969028; https://dl.ndl.go.jp/pid/9969028
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-05-01T16:38:40+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3170
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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