Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro.

• Material Type: 博士論文
• Title: Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro.
• Author/Editor: Fujita, Takahiro; Tsuruga, Eichi; Yamanouchi, Kaori; Sawa, Yoshihiko; Ishikawa, Hiroyuki
• Author Heading: Fujita, Takahiro; Tsuruga, Eichi; Yamanouchi, Kaori; Sawa, Yoshihiko; Ishikawa, Hiroyuki
• Publication Date: 2016-03-12
• Publication Date (W3CDTF): 2016-03-12
• Alternative Title: Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2016-03-12
• Date Granted (W3CDTF): 2016-03-12
• Dissertation Number: 甲第271号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第271号
• Text Language Code: eng
• Subject Heading: fibrillin; MAGP-1; 微細線維; オキシタラン線維; 毛様体小帯; microfibrils; oxytalan fibers; ciliary zonule
• Target Audience: 一般
• Note (General): The ciliary zonule in the eye, also known as Zinn's zonule, is composed of oxytalan fibers, which are bundles of microfibrils consisting mainly of fibrillin-1. However, it is still unclear which of the microfibril-associated molecules present in the ciliary zonule controls oxytalan fibers. Microfibril-associated glycoprotein-1 (MAGP-1) is the only microfibril-associated molecule identified in the human ciliary zonule. In the present study, we used siRNA against MAGP-1 in cultures of human non-pigmented ciliary epithelial cells to examine the extracellular deposition and appearance of fibrillin-1 employing Western blotting and immunofluorescence. MAGP-1 suppression led to a reduction of fibrillin-1 deposition. Immunofluorescence also confirmed that RNAi-mediated down-regulation of MAGP-1 led to suppression of fiber development. These results suggest that MAGP-1 plays a crucial role in the extracellular deposition of fibrillin-1 during formation of the human ciliary zonule.; Acta Histochem Cytochem. 2014 Feb 27;47(1):11-7. doi: 10.1267/ahc.13038. Epub 2014 Feb 18.; J-STAGE
• Persistent ID (NDL): info:ndljp/pid/9969218; https://dl.ndl.go.jp/pid/9969218
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-05-01T16:38:40+09:00
• Date Created (W3CDTF): 2016-04-22
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): Acta Histochem Cytochem. 2014 Feb 27;47(1):11-7. doi: 10.1267/ahc.13038. Epub 2014 Feb 18.; https://www.jstage.jst.go.jp/article/ahc/47/1/47_13038/_article
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/53
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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