The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells

Persistent ID (NDL): info:ndljp/pid/9984260

Material type: 博士論文

Author: Asano, Jinほか

Publisher: Springer Nature

Publication date: 2011-04-08

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: Bone marrow stromal cells (BMSCs) and osteoclasts (OCs) confer multiple myeloma (MM) cell survival through elaborating factors. We demonstrate herein ...

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Material Type: 博士論文
ISSN: 0887-6924
Title: The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells
Volume: 25 7
Author/Editor: Asano, Jin
Nakano, Ayako
Oda, Asuka
Amou, Hiroe
Hiasa, Masahiro
Takeuchi, Kyoko
Miki, Hirokazu
Nakamura, Shingen
Harada, Takeshi
Fujii, Shiro
Kagawa, Kumiko
Endo, Itsuro
Yata, Kenichiro
Sakai, Akira
Ozaki, Shuji
Matsumoto, Toshio
Abe, Masahiro
Author Heading: Asano, Jin
Nakano, Ayako
Oda, Asuka
Amou, Hiroe
Hiasa, Masahiro
Takeuchi, Kyoko
Miki, Hirokazu
Nakamura, Shingen
Harada, Takeshi
Fujii, Shiro
Kagawa, Kumiko
Endo, Itsuro
Yata, Kenichiro
Sakai, Akira
Ozaki, Shuji
Matsumoto, Toshio
Abe, Masahiro
Publication, Distribution, etc.: Springer Nature
Publication Date: 2011-04-08
Publication Date (W3CDTF): 2011-04-08
Alternative Title: セリンスレオニンキナーゼPim-2は骨髄腫における新規抗アポトーシス媒介因子である
Pim-2 in myeloma cells
Periodical title: Leukemia
Degree grantor/type: 徳島大学
Date Granted: 2014-03-19
Date Granted (W3CDTF): 2014-03-19
Dissertation Number: 甲第2741号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第2741号
Text Language Code: eng
Subject Heading: Pim-2
myeloma
bone marrow stromal cell
osteoclast
IL-6
Target Audience: 一般
Note (General): Bone marrow stromal cells (BMSCs) and osteoclasts (OCs) confer multiple myeloma (MM) cell survival through elaborating factors. We demonstrate herein that IL-6 and TNF family cytokines, TNFα, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in MM cells. BMSCs and OCs upregulate Pim-2 expression in MM cells largely via the IL-6/STAT3 and NF-ｋB pathway, respectively. Pim-2 short interfering RNA reduces MM cell viability in cocultures with BMSCs or OCs. Thus, upregulation of Pim-2 appears to be a novel anti-apoptotic mechanism for MM cell survival. Interestingly, the mammalian target of rapamycin inhibitor rapamycin further suppresses the MM cell viability in combination with the Pim-2 silencing. The Pim inhibitor (Z)-5-(4-propoxybenzylidene) thiazolidine-2, 4-dione and the PI3K inhibitor LY294002 cooperatively enhance MM cell death. The Pim inhibitor suppresses 4E-BP1 phosphorylation along with the reduction of Mcl-1 and c-Myc. Pim-2 may therefore become a new target for MM treatment.
DOI: info:doi/10.1038/leu.2011.60
https://doi.org/info:doi/10.1038/leu.2011.60
Persistent ID (NDL): info:ndljp/pid/9984260
https://dl.ndl.go.jp/pid/9984260
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2016-06-03T01:05:16+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/106134
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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