Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus(RSV)-infected mice

• Material Type: 博士論文
• Title: Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus(RSV)-infected mice
• Author/Editor: 橋口, 誠子
• Author Heading: 橋口, 誠子
• Publication Date: 2016-03-19
• Publication Date (W3CDTF): 2016-03-19
• Alternative Title: Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus(RSV)-infected mice; 二酸化チタンナノ粒子はRS ウイルス感染マウスの肺炎を悪化させる
• Degree grantor/type: 九州保健福祉大学
• Date Granted: 2016-03-19
• Date Granted (W3CDTF): 2016-03-19
• Dissertation Number: 博甲第2号
• Degree Type: 博士（医療薬学）
• Conferring No. (Dissertation): 博甲第2号
• Text Language Code: eng
• Subject Heading: Titanium dioxide; Nanoparticles; Respiratory syncytial virus; Pneumonia
• Target Audience: 一般
• Note (General): To reveal the effects of TiO2 nanoparticles, used in cosmetics and building materials, on the immune response, a respiratory syncytial virus (RSV) infection mouse model was used. BALB/c mice were exposed once intranasally to TiO2 at 0.5 mg/kg and infected intranasally with RSV five days later. The levels of IFN-γ and chemokine CCL5, representative markers of pneumonia, in the bronchoalveolar lavage fluids of RSV-infected mice had increased significantly in TiO2-exposed mice compared with the control on day 5 post-infection, but not in uninfected mice. While pulmonary viral titers were not affected by TiO2 exposure, an increase in the infiltration of lymphocytes into the alveolar septa in lung tissues was observed. Immunohistochemical analysis revealed aggregation of TiO2 nanoparticles near inflammatory cells in the severely affected region. Thus, a single exposure to TiO2 nanoparticles affected the immune system and exacerbated pneumonia in RSV-infected mice.; 平成27年度
• DOI: 10.15069/00000800; https://doi.org/10.15069/00000800
• Persistent ID (NDL): info:ndljp/pid/9984707; https://dl.ndl.go.jp/pid/9984707
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-06-03T01:05:16+09:00
• Date Created (W3CDTF): 2016-05-18
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15069/00000800; http://id.nii.ac.jp/1147/00000800/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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