Two-Fraction High-Dose-Rate Brachytherapy within a Single Day Combined with External Beam Radiotherapy for Prostate Cancer : Single Institution Experience and Outcomes.

• Material Type: 博士論文
• Title: Two-Fraction High-Dose-Rate Brachytherapy within a Single Day Combined with External Beam Radiotherapy for Prostate Cancer : Single Institution Experience and Outcomes.
• Author/Editor: Liu, Junyang
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2016-03-23
• Publication Date (W3CDTF): 2016-03-23
• Alternative Title: Two-Fraction High-Dose-Rate Brachytherapy within a Single Day Combined with External Beam Radiotherapy for Prostate Cancer : Single Institution Experience and Outcomes.; 当施設単独における前立腺癌に対する1日2回高線量率組織内照射療法の経験と結果の検討
• Degree grantor/type: 新潟大学
• Date Granted: 2016-03-23
• Date Granted (W3CDTF): 2016-03-23
• Dissertation Number: 甲第4108号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4108号
• Text Language Code: eng
• Subject Heading: High-dose-rate; Brachytherapy; HDR-BT; Radiotherapy; Prostate cancer; Toxicity
• Note (General): We investigated the outcomes of treatment for patients with localized prostate cancer (PCa) treated with three-dimensional conformal radiation therapy (3D-CRT) followed by two-fraction high-dose-rate brachytherapy within a single day (2-fr.-HDR-BT/day) at a single institution. A total of 156 consecutive Asian males (median age, 67 years) were enrolled. To compare our findings with those of other studies, we analyzed our results using the D’Amico classification, assigning the patients to low-(n=5; 3.2%), intermediate-(n=36; 23.1%), and high-risk (n=115; 73.7%) groups (stage T3 PCa patients were classified as high-risk). One patient in the D’Amico low-risk group (20%), 13 intermediate-risk patients (36.1%) and 99 high-risk patients (86.1%) underwent androgen deprivation therapy. We administered a prescription dose of 39 Gy in 13 fractions of 3D-CRT combined with 18 Gy of HDR-BT in two 9-Gy fractions delivered within a single day. We did not distinguish between risk groups in determining the prescription dose. The median follow-up period was 38 months. Of the 156 patients, one died from primary disease and five died from other diseases. The 3-year overall survival (OS) rates were 100%, 100% and 93.7% and the 3-year ‘biochemical no evidence of disease (bNED)’ rates were 100%, 100% and 96.9% for the D’Amico low-, intermediate- and high-risk groups, respectively. No patient developed≥Grade 3 early toxicity. The Grade 3 late genitourinary toxicity rate was 2.6%, and no ≥Grade 3 late gastrointestinal toxicity occurred. The efficacy and safety of this study were satisfactory, and longer-term follow-up is necessary.; 学位の種類: 博士（医学）. 報告番号: 甲第4108号. 学位記番号: 新大院博（医）甲第675号. 学位授与年月日: 平成28年3月23日; Journal of Radiation Research. First published online: March 16, 2016; 新大院博（医）甲第675号; 元資料の権利情報 : Copyright(C) The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
• DOI: info:doi/10.1093/jrr/rrw003; https://doi.org/info:doi/10.1093/jrr/rrw003
• Persistent ID (NDL): info:ndljp/pid/9984812; https://dl.ndl.go.jp/pid/9984812
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-06-03T01:05:16+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/41909
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp