Role of Maternal Antibodies in Infants with Severe Diseases Related to Human Parechovirus Type 3.

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Role of Maternal Antibodies in Infants with Severe Diseases Related to Human Parechovirus Type 3.

Persistent ID (NDL): info:ndljp/pid/9984818

Material type: 博士論文

Author: Aizawa, Yuta

Publisher: 新潟大学

Publication date: 2016-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Human parechovirus type 3 (HPeV3) is an emerging patho¬gen that causes sepsis and meningoencephalitis in young infants. To test the hypothesis that ma...

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Material Type: 博士論文
Title: Role of Maternal Antibodies in Infants with Severe Diseases Related to Human Parechovirus Type 3.
Author/Editor: Aizawa, Yuta
Publication, Distribution, etc.: 新潟大学
Publication Date: 2016-03-23
Publication Date (W3CDTF): 2016-03-23
Alternative Title: Role of Maternal Antibodies in Infants with Severe Diseases Related to Human Parechovirus Type 3.
乳児期早期のヒトパレコウイルス3型重症感染症における移行抗体の役割
Degree grantor/type: 新潟大学
Date Granted: 2016-03-23
Date Granted (W3CDTF): 2016-03-23
Dissertation Number: 甲第4126号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4126号
Text Language Code: eng
Note (General): Human parechovirus type 3 (HPeV3) is an emerging patho¬gen that causes sepsis and meningoencephalitis in young infants. To test the hypothesis that maternal antibodies can protect this population, we measured neutralizing antibody titers (NATs) to HPeV3 and other genotypes (HPeV1 and HPeV6) in 175 cord blood samples in Japan. The seroposi¬tivity rate (>1:32) for HPeV3 was 61%, similar to that for the other genotypes, but decreased significantly as ma¬ternal age increased (p<0.001). Furthermore, during the 2014 HPeV3 epidemic, prospective measurement of NATs to HPeV3 in 45 patients with severe diseases caused by HPeV3 infection showed low NATs (<1:16) at onset and persistently high NATs (>1:512) until age 6 months. All intra¬venous immunoglobulin samples tested elicited high NATs to HPeV3. Our findings indicate that maternal antibodies to HPeV3 may help protect young infants from severe dis¬eases related to HPeV3 and that antibody supplementation may benefit these patients.
学位の種類: 博士（医学）. 報告番号: 甲第4126号. 学位記番号: 新大院博（医）甲第693号. 学位授与年月日: 平成28年3月23日
Emerging Infectious Diseases. 2015, 21(11), 1966-1972.
新大院博（医）甲第693号
DOI: info:doi/10.3201/eid2111.150267
https://doi.org/info:doi/10.3201/eid2111.150267
Persistent ID (NDL): info:ndljp/pid/9984818
https://dl.ndl.go.jp/pid/9984818
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2016-06-03T01:05:16+09:00
Date Created (W3CDTF): 2019-08-05
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/41921
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp