Prognostic factors and causes of death in patients cured of esophageal cancer.

• Material Type: 博士論文
• Title: Prognostic factors and causes of death in patients cured of esophageal cancer.
• Author/Editor: Kakuta, Tomoyuki
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2016-03-23
• Publication Date (W3CDTF): 2016-03-23
• Alternative Title: Prognostic factors and causes of death in patients cured of esophageal cancer.; 食道癌切除後長期生存患者における予後因子と死因についての検討
• Degree grantor/type: 新潟大学
• Date Granted: 2016-03-23
• Date Granted (W3CDTF): 2016-03-23
• Dissertation Number: 甲第4130号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4130号
• Text Language Code: eng
• Note (General): Background: The number of patients cured of esophageal cancer after esophagectomy is gradually increasing owning to advances in surgical techniques, perioperative management, and adjuvant therapies. This study assessed the clinical course and sought to identify the prognostic factors of these patients. Methods: A series of 220 consecutive patients who underwent esophagectomy and survived for more than 5 years with no relapse were enrolled. Survival analysis was performed using 25 variables including patient characteristics and operative and perioperative factors. Potential prognostic factors were identified by univariate and multivariate analyses, and the development of other primary cancers and the causes of death were retrospectively reviewed. Results: The overall 10-, 15-, and 20-year survival rates were 71.6, 50.1, and 32.2%, respectively, with a median survival time of 180 months (range, 61–315 months). The negative independent prognostic factors identified were age at surgery (hazard ratio[HR], 1.05;P<0.01), being male (HR, 2.62; P=0.02), pulmonary comorbidities (HR, 2.03; P=0.02), synchronous presence of other cancers (HR, 2.35; P<0.01), colonic/jejunal interposition (HR, 1.76; P=0.03), perioperative blood transfusion (HR, 1.92; P=0.02), development of pulmonary complications (HR, 1.71; P=0.02), and adjuvant radiotherapy (HR, 2.13; P=0.01). Pulmonary diseases and other primary cancers were found to be the most common causes of death. Conclusions: Careful follow up including the surveillance of other primary cancers is required for long-term survivors of esophageal cancer after esophagectomy.; 学位の種類: 博士（医学）. 報告番号: 甲第4130号. 学位記番号: 新大院博（医）甲第697号. 学位授与年月日: 平成28年3月23日; Annals of Surgical Oncology. 2014, 21(5), 1749-1755.; 新大院博（医）甲第697号; 元資料の権利情報 : The final publication is available at Springer via http://dx.doi.org/10.1245/s10434-014-3499-7; 開始ページ : 1; 終了ページ : 26
• DOI: info:doi/10.1245/s10434-014-3499-7; https://doi.org/info:doi/10.1245/s10434-014-3499-7
• Persistent ID (NDL): info:ndljp/pid/9984820; https://dl.ndl.go.jp/pid/9984820
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-06-03T01:05:16+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/41925
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp