CYP1A1, GSTM1, GSTT1, and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians

• Material Type: 博士論文
• Title: CYP1A1, GSTM1, GSTT1, and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians
• Author/Editor: Sakai, Kazuaki
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2016-03-23
• Publication Date (W3CDTF): 2016-03-23
• Alternative Title: CYP1A1, GSTM1, GSTT1, and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians; ボリビア人におけるCYP1A1、GSTM1、GSTT1、TP53 遺伝子多型と胆嚢がん発症リスク
• Degree grantor/type: 新潟大学
• Date Granted: 2016-03-23
• Date Granted (W3CDTF): 2016-03-23
• Dissertation Number: 甲第4133号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4133号
• Text Language Code: eng
• Subject Heading: Gallbladder cancer; genetic susceptibility; CYP1A1; GSTM1; GSTT1; TP53
• Note (General): The Plurinational State of Bolivia (Bolivia) has a high incidence rate of gallbladder cancer (GBC). However, the genetic and environmental risk factors for GBC development are not well understood. We aimed to assess whether or not cytochrome P450, (CYP1A1), glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1) and tumor suppressor protein p53 (TP53) genetic polymorphisms modulate GBC susceptibility in Bolivians. This case-control study covered32 patients with GBC and 86 healthy subjects. GBC was diagnosed on the basis of histological analysis of tissues at the Instituto de Gastroenterologia Boliviano-Japones (IGBJ); the healthy subjects were members of the staff at the IGBJ. Distributions of the CYP1A1 rs1048943 and TP53 rs1042522 polymorphisms were assayed using PCR-restriction fragment length polymorphism assay. GSTM1 and GSTT1 deletion polymorphisms were detected by a multiplex PCR assay. The frequency of the GSTM1 null genotype was significantly higher in GBC patients than in the healthy subjects (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.03-5.37; age-adjusted OR, 3.53; 95% CI, 1.29-9.66; age- and sex-adjusted OR, 3.40; 95% CI, 1.24-9.34). No significant differences were observed in the frequencies of CYP1A1, GSTT1, or TP53 polymorphisms between the two groups. The GSTM1 null genotype was associated with increased GBC risk in Bolivians. Additional studies with larger control and case populations are warranted to confirm the association between the GSTM1 deletion polymorphism and GBC risk suggested in the present study.; 学位の種類: 博士（医学）. 報告番号: 甲第4133号. 学位記番号: 新大院博（医）甲第700号. 学位授与年月日: 平成28年3月23日; Asian Pacific Journal of Cancer Prevention. 2016, 17(2), 781-784.; 新大院博（医）甲第700号; 開始ページ : 1; 終了ページ : 4
• DOI: info:doi/10.7314/APJCP.2016.17.2.781; https://doi.org/info:doi/10.7314/APJCP.2016.17.2.781
• Persistent ID (NDL): info:ndljp/pid/9984823; https://dl.ndl.go.jp/pid/9984823
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-06-03T01:05:16+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://hdl.handle.net/10191/41929
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp