Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.

• Material Type: 博士論文
• ISSN: 0304-3940
• Title: Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.
• Volume: 591
• Author/Editor: KATO, Tomoko
• Author Heading: KATO, Tomoko
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2015-03-30
• Publication Date (W3CDTF): 2015-03-30
• Periodical title: Neuroscience letters
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2015-09-09
• Date Granted (W3CDTF): 2015-09-09
• Dissertation Number: 乙第420号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第420号
• Text Language Code: eng
• Subject Heading: Alzheimer's disease; α1-chimaerin; Rac1; In situ hybridization; real-time PCR
• Target Audience: 一般
• Note (General): Alpha1-chimaerin is a GTPase-activating protein (GAP) for Rac1, a member of the Rho small GTPase family, whose action leads to the inactivation of Rac1. Rac1 activity is upregulated in Alzheimer's disease, but little is known about the role of α1-chimaerin. In this study, we investigated the expression and localization of α1-chimaerin mRNA in postmortem human brains from patients with Alzheimer's disease and control subjects. In situ hybridization studies demonstrated that α1-chimaerin was expressed by neurons in the neo-cortex of the temporal lobe and the hippocampus of both controls and Alzheimer's disease cases, with the signal intensity dramatically decreased in patients with Alzheimer's disease. Real-time PCR analysis confirmed a significant reduction of α1-chimaerin mRNA expression in the temporal cortex of Alzheimer's disease cases. In contrast, α2-chimaerin mRNA levels showed no significant difference between the groups. The present study showed reduced α1-chimaerin expression in the brain of Alzheimer's disease cases, suggesting a role in the upregulation of Rac1 activity during the disease process.; Thesis or Dissertation; 平成27年度; 10.1016/j.neulet.2015.02.013
• DOI: info:doi/10.1016/j.neulet.2015.02.013; https://doi.org/info:doi/10.1016/j.neulet.2015.02.013
• Persistent ID (NDL): info:ndljp/pid/9984839; https://dl.ndl.go.jp/pid/9984839
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2016-06-03T01:05:16+09:00
• Date Created (W3CDTF): 2017-02-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/11671; https://shiga-med.repo.nii.ac.jp/records/1379
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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