Local cytomegalovirus infection in patients with diarrhea following allogeneic stem cell transplantation

• 資料種別: 記事
• タイトル: Local cytomegalovirus infection in patients with diarrhea following allogeneic stem cell transplantation
• 著者・編者: 二宮 一郎; 中島 衡; 権藤 久司 他
• 著者標目: 二宮 一郎; 中島 衡; 権藤 久司
• 並列タイトル等: 同種造血幹細胞移植後,下痢を呈した患者の消化管サイトメガロウイルス感染
• タイトル（掲載誌）: 福岡医学雑誌 = Fukuoka acta medica
• 巻号年月日等（掲載誌）: 98(4) (通号 1027) 2007.4.25
• 掲載巻: 98
• 掲載号: 4
• 掲載通号: 1027
• 掲載ページ: 114～123
• 掲載年月日（W3CDTF）: 2007-04-25
• ISSN（掲載誌）: 0016-254X
• ISSN-L（掲載誌）: 0016-254X
• 出版事項（掲載誌）: 福岡 : 福岡医学会
• 出版地（国名コード）: JP
• 本文の言語コード: eng
• NDLC: ZS7
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z19-86
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 8826836; http://id.ndl.go.jp/bib/8826836
• 整理区分コード: 632

• 要約等: To evaluate local cytomegalovirus (CMV)infection in patients who developed diarrhea after allogeneic hematopoietic stem cell transplantation (HSCT), histologic and molecular analysis was carried out with intestinal biopsy samples from 17 transplant recipients. A CMV-specific intranuclear inclusion body indicating intestinal CMV disease was documented in 2 biopsy samples. CMV DNA was detected by quantitative polymerase chain reaction in 8 of 23 (34.8%)samples,including 2 samples diagnosed with intestinal CMV disease. Of 15 patients without histologic confirmation of intestinal CMV disease,pre-emptive therapy was carried out for 8 patients based on positive antigenemia, and for 2 patients on positive CMV DNA, respectively. Intestinal CMV disease was successfully treated with antiviral therapy for 2 patients and prevented with pre-emptive therapy based on either positive antigenemia or positive CMV DNA for 10 patients. Endoscopic examinations with histologic and molecular analysis may be important in the early treatment and the prevention of intestinal CMV disease in patients with diarrhea after allogeneic stem cell transplantation.
• DOI: 10.15017/4284; https://doi.org/10.15017/4284
• オンライン閲覧公開範囲: インターネット公開
• 掲載誌（NCID）: AN00215478; https://ci.nii.ac.jp/ncid/AN00215478
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 九州大学学術情報リポジトリ(QIR); https://www.lib.kyushu-u.ac.jp/papers

• 要約等: To evaluate local cytomegalovirus (CMV)infection in patients who developed diarrhea after allogeneic hematopoietic stem cell transplantation (HSCT), histologic and molecular analysis was carried out with intestinal biopsy samples from 17 transplant recipients. A CMV-specific intranuclear inclusion body indicating intestinal CMV disease was documented in 2 biopsy samples. CMV DNA was detected by quantitative polymerase chain reaction in 8 of 23 (34.8%)samples,including 2 samples diagnosed with intestinal CMV disease. Of 15 patients without histologic confirmation of intestinal CMV disease,pre-emptive therapy was carried out for 8 patients based on positive antigenemia, and for 2 patients on positive CMV DNA, respectively. Intestinal CMV disease was successfully treated with antiviral therapy for 2 patients and prevented with pre-emptive therapy based on either positive antigenemia or positive CMV DNA for 10 patients. Endoscopic examinations with histologic and molecular analysis may be important in the early treatment and the prevention of intestinal CMV disease in patients with diarrhea after allogeneic stem cell transplantation.
• DOI: 10.15017/4284; https://doi.org/10.15017/4284
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（URI）: https://hdl.handle.net/2324/4284; http://id.ndl.go.jp/bib/8826836; https://ndlsearch.ndl.go.jp/books/R000000004-I8826836; https://search.jamas.or.jp/link/ui/2007299729
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 学術機関リポジトリデータベース; https://irdb.nii.ac.jp; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles
• 書誌ID（NDLBibID）: 8826836; http://id.ndl.go.jp/bib/8826836
• NII論文ID: 120000986713