The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis.

• Material Type: 博士論文
• Title: The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis.
• Author/Editor: Ogata, Kayoko; Tsumuraya, Tomoyuki; Oka, Kyoko; Shin, Masashi; Okamoto, Fujio; Kajiya, Hiroshi; Katagiri, Chiaki; Ozaki, Masao; Matsushita, Masayuki; Okabe, Koji
• Author Heading: Ogata, Kayoko; Tsumuraya, Tomoyuki; Oka, Kyoko; Shin, Masashi; Okamoto, Fujio; Kajiya, Hiroshi; Katagiri, Chiaki; Ozaki, Masao; Matsushita, Masayuki; Okabe, Koji
• Publication Date: 2018-03-29
• Publication Date (W3CDTF): 2018-03-29
• Alternative Title: The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2018-03-29
• Date Granted (W3CDTF): 2018-03-29
• Dissertation Number: 甲第297号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第297号
• Text Language Code: eng
• Subject Heading: エナメル質; 石灰化; TRPM7; キナーゼ; イオンチャネル; enamel; mineralization; kinase; ion channel
• Target Audience: 一般
• Note (General): Transient receptor potential melastatin-7 (TRPM7) is a bi-functional protein containing a kinase domain fused to an ion channel. TRPM7 is highly expressed in ameloblasts during tooth development. Here we show that TRPM7 kinase-inactive knock-in mutant mice (TRPM7 KR mice) exhibited small enamel volume with opaque white-colored incisors. The TRPM7 channel function of ameloblast-lineage cells from TRPM7 KR mice was normal. Interestingly, phosphorylation of intracellular molecules including Smad1/5/9, p38 and cAMP response element binding protein (CREB) was inhibited in ameloblasts from TRPM7 KR mice at the pre-secretory stage. An immunoprecipitation assay showed that CREB was bound to TRPM7, suggesting that direct phosphorylation of CREB by TRPM7 was inhibited in ameloblast-lineage cells from TRPM7 KR mice. These results indicate that the function of the TRPM7 kinase domain plays an important role in ameloblast differentiation, independent of TRPM7 channel activity, via phosphorylation of CREB.; Scientific Reports
• Persistent ID (NDL): info:ndljp/pid/11092179; https://dl.ndl.go.jp/pid/11092179
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
• Date Created (W3CDTF): 2018-04-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://www.nature.com/articles/s41598-017-18291-0
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/82
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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