ルビスコリン-６はオピオイド受容体を活性化することで骨格筋の糖取込みを促進する 1

• Material Type: 博士論文
• Title: ルビスコリン-６はオピオイド受容体を活性化することで骨格筋の糖取込みを促進する
• Volume: 27 1
• Author/Editor: Kairupan, Timothy Sean
• Author Heading: Kairupan, Timothy Sean
• Publication, Distribution, etc.: Food and Drug Administration
• Publication Date: 2019; 27 1
• Publication Date (W3CDTF): 2019
• Alternative Title: Rubiscolin-6 activates opioid receptors to enhance glucose uptake in skeletal muscle
• Periodical title: Journal of Food and Drug Analysis
• Pages: 266-274
• Degree Grantor: 鹿児島大学
• Date Granted: 2019-03-19
• Date Granted (W3CDTF): 2019-03-19
• Dissertation Number: 甲総研第495号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: AMPK; Glucose Uptake; GLUT4; Opioid Receptor; Rubiscolin-6
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Rubiscolin-6 is an opioid peptide derived from plant ribulose bisphosphate carboxylase/oxygenase (Rubisco). It has been demonstrated that opioid receptors could control glucose homeostasis in skeletal muscle independent of insulin action. Therefore, Rubiscolin-6 may be involved in the control of glucose metabolism. In the present study, we investigated the effect of rubiscolin-6 on glucose uptake in skeletal muscle. Rubiscolin-6-induced glucose uptake was measured using the fluorescent indicator 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxyglucose (2-NBDG) in L6 and C2C12 cell lines. The protein expressions of glucose transporter 4 (GLUT4) and AMP-activated protein kinase (AMPK) in L6 cells were observed by Western blotting. The in vivo effects of rubiscolin-6 were characterized in streptozotocin (STZ)-induced diabetic rats. Rubiscolin-6 induced a concentration-dependent increase in glucose uptake levels. The increase of phospho-AMPK (pAMPK) and GLUT4 expressions were also observed in L6 and C2C12 cells. Effects of rubiscolin-6 were blocked by opioid receptor antagonists and/or associated signals inhibitors. Moreover, Rubiscolin-6 produced a dose-dependent reduction of blood glucose and increased GLUT4 expression in STZ-induced diabetic rats. In conclusion, rubiscolin-6 increases glucose uptake, potentially via an activation of AMPK to enhance GLUT4 translocation after binding to opioid receptors in skeletal muscle.; 機関リポジトリ記載の権利情報: © 2018 Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
• Persistent ID (NDL): info:ndljp/pid/11426693; https://dl.ndl.go.jp/pid/11426693
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): https://www.jfda-online.com/; https://doi.org/10.1016/j.jfda.2018.06.012
• Periodical Title (URI): http://hdl.handle.net/10232/00030532
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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