Label-free classification of cells based on supervised machine learning of subcellular structures

• Material Type: 博士論文
• ISSN: 1932-6203
• Title: Label-free classification of cells based on supervised machine learning of subcellular structures
• Volume: 14 1
• Author/Editor: 尾﨑, 裕介
• Author Heading: 尾﨑, 裕介
• Publication, Distribution, etc.: PLoS (Public Library of Science)
• Publication Date: 2019-01-29
• Publication Date (W3CDTF): 2019-01-29
• Alternative Title: 細胞内構造の教師付き機械学習に基づいた非標識による細胞分類
• Periodical title: PloS one
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-04-19
• Date Granted (W3CDTF): 2019-04-19
• Dissertation Number: 甲第816号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第816号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; It is demonstrated that cells can be classified by pattern recognition of the subcellular structure of non-stained live cells, and the pattern recognition was performed by machine learning. Human white blood cells and five types of cancer cell lines were imaged by quantitative phase microscopy, which provides morphological information without staining quantitatively in terms of optical thickness of cells. Subcellular features were then extracted from the obtained images as training data sets for the machine learning. The built classifier successfully classified WBCs from cell lines (area under ROC curve=0.996). This label-free, non-cytotoxic cell classification based on the subcellular structure of QPM images has the potential to serve as an automated diagnosis of single cells.
• DOI: info:doi/10.1371/journal.pone.0211347; https://doi.org/info:doi/10.1371/journal.pone.0211347
• Persistent ID (NDL): info:ndljp/pid/11458380; https://dl.ndl.go.jp/pid/11458380
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-03-11T23:38:06+09:00
• Date Created (W3CDTF): 2020-02-25
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003678; https://hama-med.repo.nii.ac.jp/records/3541
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-09 再収集