Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study

• Material Type: 博士論文
• ISSN: 1465-3621
• Title: Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study
• Volume: 50 5
• Author/Editor: 松川, 京子
• Author Heading: 松川, 京子
• Publication, Distribution, etc.: Oxford University Press
• Publication Date: 2020-09-02; 50 5
• Publication Date (W3CDTF): 2020-09-02
• Alternative Title: 日本における前立腺癌患者の陽子線治療による健康関連QOL：単施設コホート研究
• Periodical title: Japanese Journal of Clinical Oncology
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2020-09-02
• Date Granted (W3CDTF): 2020-09-02
• Dissertation Number: 甲医歯薬第1281号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1281号
• Text Language Code: eng
• Subject Heading: prostate cancer; proton beam therapy; health-related quality of life; Japanese patients
• Target Audience: 一般
• Note (General): Objective: Many treatment options have guaranteed long-term survival in patients with localized prostate cancer and health-related quality of life has become a greater concern for those patients. The purpose of this study was to reveal the health-related quality of life after proton beam therapy and to clarify the differences from other treatment modalities for prostate cancer. Methods: Between January 2011 and April 2016, 583 patients were enrolled in the study and health-related quality of life outcomes using the Expanded Prostate Cancer Index Composite questionnaire were evaluated and compared with previous research targeted at Japanese patients. Results: We found a significant decrease in the least square mean scores for urinary and bowel domains excluding the incontinence subscale after proton beam therapy (P < 0.0001) and recovery at a year following treatment. The scores for sexual function in patients without androgen deprivation therapy decreased each year after proton beam therapy (P < 0.0001). The scores for hormones in patients without androgen deprivation therapy remained high and those of patients with androgen deprivation therapy were lower before treatment but were comparable to those of non-androgen deprivation therapy patients at 2 years post-treatment. We found that the impact of radiotherapy including proton beam therapy on urinary condition and sexual function was lower than that of surgery. Conclusions: For the first time in Japan, we investigated health-related quality of life using Expanded Prostate Cancer Index Composite questionnaires in patients with prostate cancer after proton beam therapy and compared it with other treatment modalities.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1281号 学位授与年月日:令和2年9月2日; Author: Kyoko Matsukawa, Takeshi Arimura, Makiko Orita, Hisayoshi Kondo, Ikuko Chuman, Takashi Ogino, Yasuyuki Taira, Takashi Kudo, Noboru Takamura; Citation: Japanese Journal of Clinical Oncology, 50(5), pp.519?527; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02)
• DOI: info:doi/10.1093/jjco/hyaa027; https://doi.org/info:doi/10.1093/jjco/hyaa027
• Persistent ID (NDL): info:ndljp/pid/11552088; https://dl.ndl.go.jp/pid/11552088
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-10-06T21:18:06+09:00
• Date Created (W3CDTF): 2020-12-16
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10069/40352
• Periodical Title (URI): http://hdl.handle.net/10069/40292
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集