Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway

Persistent ID (NDL): info:ndljp/pid/12071517

Material type: 博士論文

Author: 今井, 一貴

Publisher: -

Publication date: 2020-03-06

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Shikonin is an active ingredient in Lithospermum erythrorhizon that　promotes wound healing. We examined wound healing by shikonin using human　gingival...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway
Author/Editor: 今井, 一貴
Author Heading: 今井, 一貴
Publication Date: 2020-03-06
Publication Date (W3CDTF): 2020-03-06
Alternative Title: ERK1/2 シグナル伝達経路を介したヒト歯肉線維芽細胞におけるShikonin の生物学的効果
Degree grantor/type: 大阪歯科大学
Date Granted: 2020-03-06
Date Granted (W3CDTF): 2020-03-06
Dissertation Number: 甲第860号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第860号
Text Language Code: eng
Subject Heading: Shikonin ｜Wound healing ｜Gingival Fibroblasts
Target Audience: 一般
Note (General): Shikonin is an active ingredient in Lithospermum erythrorhizon that　promotes wound healing. We examined wound healing by shikonin using human　gingival fibroblasts (hGF) collected from patients. We determined the optimal　concentration from the result of cell proliferation and migration. And then we　investigated the expression of VEGF, FN and Type I collagen. Moreover, we examined　the phosphorylation of ERK 1/2 involved in wound healing. Finally, we performed all experiments using ERK 1/2 specific inhibitor (PD98059).Shikonin 1μM significantly promote cell proliferation and migration, shikonin promoted the expression of VEGF, FN and Type I collagen. Also, shikonin enhanced the activation of ERK 1/2 phosphorylation PD98059 suppressed the these effects of shikonin. In conclusion, wefound that shikonin might be useful in gingival wound healing.
2019年度
Persistent ID (NDL): info:ndljp/pid/12071517
https://dl.ndl.go.jp/pid/12071517
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2020-04-28
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000223/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp