Plasma Renin Activity Is an Independent Prognosticator in Patients With Myocardial Infarction. 6

• Material Type: 博士論文
• ISSN: 1346-9843
• Title: Plasma Renin Activity Is an Independent Prognosticator in Patients With Myocardial Infarction.
• Volume: 83 6
• Author/Editor: Kamon, Daisuke; Okura, Hiroyuki; Okamura, Akihiko; Nakada, Yasuki; Hashimoto, Yukihiro; Sugawara, Yu; Ueda, Tomoya; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawakami, Rika; Saito, Yoshihiko
• Author Heading: Kamon, Daisuke; Okura, Hiroyuki; Okamura, Akihiko; Nakada, Yasuki; Hashimoto, Yukihiro; Sugawara, Yu; Ueda, Tomoya; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawakami, Rika; Saito, Yoshihiko
• Publication, Distribution, etc.: 日本循環器学会 / Japanese Circulation Society
• Publication Date: 2019-05-24; 83 6
• Publication Date (W3CDTF): 2019-05-24
• Alternative Title: 血漿レニン活性値は、急性心筋梗塞患者の独立した予後予測因子である
• Periodical title: Circulation journal
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-06-30
• Date Granted (W3CDTF): 2020-06-30
• Dissertation Number: 甲第745号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第745号
• Text Language Code: eng
• Subject Heading: Acute myocardial infarction; Plasma renin activity; Prognosis
• Target Audience: 一般
• Note (General): type:Thesis; Background: Plasma renin activity (PRA) is associated with cardiovascular events in patients with heart failure (HF), but its prognostic role in acute myocardial infarction (AMI) is unclear. Methods and Results: A total of 878 patients with information on baseline PRA on admission were selected from 1,055 AMI patients who underwent emergency coronary angiography between 2007 and 2016. The patients were divided into 2 groups according to their median PRA (2.0 ng/mL/h). The primary endpoint was major adverse cardiac events (MACE), defined as a composite of cardiovascular death and hospitalization because of HF. During follow-up (median 4.5±3.1 years), MACE occurred in 108 patients. Kaplan-Meier analysis showed that the high PRA group had significantly lower MACE-free survival than the low PRA group (log-rank P=0.0009). By multivariate analysis, high PRA was an independent predictor of MACE (hazard ratio (HR) 1.573; 95% confidence interval (CI) 1.049–2.396, P=0.0282). Similarly, among 580 patients who had not been previously treated with renin-angiotensin system inhibitors or β-blockers on admission, high PRA was an independent predictor of MACE (HR 1.732; 95% CI 1.010–3.047, P=0.0460). Conclusions: In the studied AMI patients, elevated levels of PRA were independently associated with poor prognosis.; 博士（医学）・甲第745号・令和2年6月30日; 日本循環器学会の許諾を得て登録（2020年10月19日付）; ジャーナル公式サイト（日本循環器学会HP内）：https://www.j-circ.or.jp/journal/; 公開サイト（J-STAGE）：https://www.jstage.jst.go.jp/browse/circj/; identifier:Circulation journal Vol.83 No.6 p.1324-1329 (2019 May); identifier:13469843; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3752; identifier:Circulation journal, 83(6): 1324-1329
• DOI: info:doi/10.1253/circj.CJ-18-1195; https://doi.org/info:doi/10.1253/circj.CJ-18-1195
• Persistent ID (NDL): info:ndljp/pid/12263269; https://dl.ndl.go.jp/pid/12263269
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3752
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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