Effect of Non-Thermal Atmospheric Pressure Plasma on Differentiation Potential of Human Deciduous Dental Pulp Fibroblast-like Cells
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- Material Type
- 博士論文
- Author/Editor
- 奥野, 真江
- Author Heading
- Publication Date
- 2022-03-04
- Publication Date (W3CDTF)
- 2022-03-04
- Alternative Title
- 非熱的大気圧プラズマがヒト乳歯歯髄線維芽細胞の分化能に及ぼす影響
- Degree Grantor
- 大阪歯科大学
- Date Granted
- 2022-03-04
- Date Granted (W3CDTF)
- 2022-03-04
- Dissertation Number
- 甲第920号
- Degree Type
- 博士（歯学）
- Conferring No. (Dissertation)
- 甲第920号
- Text Language Code
- eng
- Subject Heading
- Target Audience
- 一般
- Note (General)
- Human mesenchymal stem cells can differentiate into various cell types and are useful for applications in regenerative medicine. Previous studies indicated that dental pulp exfoliated from deciduous teeth is a valuable alternative for dental tissue engineering because it contains stem cells with a relatively high proliferation rate. For clinical application, it is necessary to rapidly obtain a sufficient number of cells in vitro and maintain their undifferentiated state; however, the abundance of stem cells in the dental pulp tissue is limited. Non-thermal atmospheric pressure plasma (NTAPP) has been applied in regenerative medicine because it activates cell proliferation. Here, we examined the effects of NTAPP to activate the proliferation of human deciduous dental pulp fibroblast-like cells (hDDPFs) in vitro. Compared with untreated cells, NTAPP increased cell proliferation by 1.3-fold, significantly upregulated well-known pluripotent genes for stemness (e.g., Oct4, Sox2, and Nanog), and activated the expression of stem cell-specific surface markers (e.g., CD105). Overall, NTAPP activated the proliferation of various mesodermal-derived human adult stem cells while maintaining their pluripotency and stemness. In conclusion, NTAPP is a potential tool to expand the population of various adult stem cells in vitro for medical applications.2021年度機関リポジトリ記載の権利情報: CC BY-NC-ND
- Persistent ID (NDL)
- info:ndljp/pid/12296876
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- Acquisition Basis
- 博士論文（自動収集）
- Date Accepted (W3CDTF)
- 2022-06-05T18:01:14+09:00
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション