Effects of amelogenin synthetic peptide on cell proliferation and cell adhesion in human periodontal ligament stem cells

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Effects of amelogenin synthetic peptide on cell proliferation and cell adhesion in human periodontal ligament stem cells

Persistent ID (NDL): info:ndljp/pid/12297223

Material type: 博士論文

Author: 陳, 怡潔

Publisher: -

Publication date: 2021-09-22

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: In our previous study, we constructed a synthetic peptide (SP) derived from enamel matrix derivative that had the potential to form hard tissue. Perio...

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Material Type: 博士論文
Title: Effects of amelogenin synthetic peptide on cell proliferation and cell adhesion in human periodontal ligament stem cells
Author/Editor: 陳, 怡潔
Author Heading: 陳, 怡潔
Publication Date: 2021-09-22
Publication Date (W3CDTF): 2021-09-22
Alternative Title: ヒト歯根膜幹細胞に対するアメロジェニンペプチドの増殖と接着への影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2021-09-22
Date Granted (W3CDTF): 2021-09-22
Dissertation Number: 乙第1637号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 乙第1637号
Text Language Code: eng
Subject Heading: Enamel matrix derivative
Periodontal ligament stem cells
MAP kinase signal
Target Audience: 一般
Note (General): In our previous study, we constructed a synthetic peptide (SP) derived from enamel matrix derivative that had the potential to form hard tissue. Periodontal ligament stem cells (PDLSCs) can contribute to periodontal tissue regeneration. We investigated the effect of SP on human PDLSCs obtained from healthy adult human third molars. Cell proliferation and cell adhesion were examined by culturing the PDLSCs with and without the SP. The effect of SP on the ERK 1/2 pathway was investigated by western blot analysis. The proliferation of PDLSCs were promoted by SP, which significantly enhanced the cell adhesion of the PDLSCs. The ERK 1/2 signaling pathway was activated by SP and the molecular effect was suppressed by ERK 1/2 specific inhibitor (PD98059). We hypothesized that SP activated the cell proliferation and cell adhesion through the ERK 1/2 pathway. These results indicated that SP might enhance periodontal tissue regeneration.
2021年度
Persistent ID (NDL): info:ndljp/pid/12297223
https://dl.ndl.go.jp/pid/12297223
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
Date Created (W3CDTF): 2021-10-12
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000288/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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