Verification of improvement of periorbital wrinkles by using Asakado Skin Care

• Material Type: 記事
• Title: Verification of improvement of periorbital wrinkles by using Asakado Skin Care
• Author/Editor: Yoshikazu Yonei; Masayuki Yagi
• Publication, Distribution, etc.: 日本 : 糖化ストレス研究会
• Publication Date: 2023-03-31
• Publication Date (W3CDTF): 2023-03-31
• Alternative Title: Asakado浅花堂スキンケア使用による目尻のシワ改善効果の検証腸脳力を活かした質の高い健康長寿実現のアプローチ
• Periodical title: Glycative stress research
• No. or year of volume/issue: 10(1)
• Volume: 10(1)
• ISSN (Periodical Title): 2188-3610
• ISSN-L (Periodical Title): 2188-3610
• Text Language Code: eng; jpn
• DOI: 10.24659/gsr.10.1_27; https://doi.org/10.24659/gsr.10.1_27
• Persistent ID (NDL): info:ndljp/pid/13120796; https://dl.ndl.go.jp/pid/13120796
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• Acquisition Basis: オンライン資料収集制度
• Date Accepted (W3CDTF): 2023-12-08T11:19:23+09:00
• Date Captured (W3CDTF): 2023-05-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://www.toukastress.jp/webj/
• Periodical Title (Persistent ID (NDL)): info:ndljp/pid/13120792; https://dl.ndl.go.jp/pid/13120792
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Collection (particular): 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Holding library: 国立国会図書館
• Call No.: Z63-D541
• Related Material (URI): https://dl.ndl.go.jp/info:ndljp/pid/13120796
• Related Material (Persistent ID (NDL)): info:ndljp/pid/13120796; https://dl.ndl.go.jp/info:ndljp/pid/13120796
• Data Provider (Database): 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• Bibliographic ID (NDL): 033430116; http://id.ndl.go.jp/bib/033430116
• Bibliographic Record Category (NDL): 632

• Summary, etc.: The present study conducted a trial for a skin application of a test cosmetic product with 34 healthy women aged between 35 to 55 years of age (43.4 ± 0.6) who satisfied the classification of 1, 2, and 3 in the standards for the wrinkle grade assessment in accordance with "Guidelines for Evaluation of Cosmetic Functions". In a half face method for 8 weeks, the test cosmetic sample was applied to one lateral periorbital lines of a face (applied side) twice a day and no treatment was applied over the other periorbital lines (non-applied side). The test product was a skin-care cosmetic that contained diverse constituents such as <i>Ceratonia siliqua</i> L. fruit extract, <i>Polygonum tinctorium</i> leaf/stem extract, and ribosomal constituents. In test results after 8 weeks for the primary endpoint of grade assessments of periorbital wrinkles, the grade on the applied side indicated significant improvements through a visual assessment during a medical examination and a visual assessment of observing case photographic images by medical specialists. However, results of the primary endpoint on the non-applied side also indicated significant improvements. There was no significant difference between two sides. Replica analysis examining periorbital wrinkles did not suggest any significant changes between on applied or non-applied side as well as between before and after test product application. Secondary endpoint of skin viscoelasticity (R2) significantly improved on the applied and non-applied sides after 8 weeks. There was no significant difference of changes in quantity. In the process of the trial, no adverse event was reported and the safety of the test product was confirmed. We conducted a further investigation to explore possibilities that diverse functional ingredients contained in this product were absorbed through percutaneous absorption with an assistance of ribosomal constituents, and exerted effects toward the other side of the face. To verify this hypothesis, further examinations are required to confirm blood concentrations of active components after tests.
• DOI: 10.24659/gsr.10.1_27
• Access Restrictions: インターネット公開
• Data Provider (Database): 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• Summary, etc.: The present study conducted a trial for a skin application of a test cosmetic product with 34 healthy women aged between 35 to 55 years of age (43.4 ± 0.6) who satisfied the classification of 1, 2, and 3 in the standards for the wrinkle grade assessment in accordance with "Guidelines for Evaluation of Cosmetic Functions". In a half face method for 8 weeks, the test cosmetic sample was applied to one lateral periorbital lines of a face (applied side) twice a day and no treatment was applied over the other periorbital lines (non-applied side). The test product was a skin-care cosmetic that contained diverse constituents such as <i>Ceratonia siliqua</i> L. fruit extract, <i>Polygonum tinctorium</i> leaf/stem extract, and ribosomal constituents. In test results after 8 weeks for the primary endpoint of grade assessments of periorbital wrinkles, the grade on the applied side indicated significant improvements through a visual assessment during a medical examination and a visual assessment of observing case photographic images by medical specialists. However, results of the primary endpoint on the non-applied side also indicated significant improvements. There was no significant difference between two sides. Replica analysis examining periorbital wrinkles did not suggest any significant changes between on applied or non-applied side as well as between before and after test product application. Secondary endpoint of skin viscoelasticity (R2) significantly improved on the applied and non-applied sides after 8 weeks. There was no significant difference of changes in quantity. In the process of the trial, no adverse event was reported and the safety of the test product was confirmed. We conducted a further investigation to explore possibilities that diverse functional ingredients contained in this product were absorbed through percutaneous absorption with an assistance of ribosomal constituents, and exerted effects toward the other side of the face. To verify this hypothesis, further examinations are required to confirm blood concentrations of active components after tests.
• DOI: 10.24659/gsr.10.1_27; https://doi.org/10.24659/gsr.10.1_27
• Related Material (URI): http://id.ndl.go.jp/bib/033430116; https://ndlsearch.ndl.go.jp/books/R000000004-I033430116; https://dl.ndl.go.jp/pid/13120796; http://id.ndl.go.jp/digimeta/13120796; https://search.jamas.or.jp/link/ui/2024180407
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp
• Bibliographic ID (NDL): 033430116; http://id.ndl.go.jp/bib/033430116; 13120796; http://id.ndl.go.jp/bib/13120796