マウスへの桑の葉投与が腸内細菌叢と代謝物に及ぼす影響に関する基礎研究
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DOI[10.14943/doctoral.k15675]to the data of the same series
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- Material Type
- 博士論文
- Author/Editor
- 甘, 莉
- Author Heading
- Publication, Distribution, etc.
- Publication Date
- 2023-12-25
- Publication Date (W3CDTF)
- 2023-12-25
- Alternative Title
- A Basic Study of the Effects of Mulberry Leaf Administration to Mice on Gut Microbiota and Metabolites
- Contributor
- 相沢, 智康芳賀, 永中村, 公則
- Degree Grantor
- 北海道大学
- Date Granted
- 2023-12-25
- Date Granted (W3CDTF)
- 2023-12-25
- Dissertation Number
- 甲第15675号
- Degree Type
- 博士(ソフトマター科学)
- Text Language Code
- eng
- NDC
- Target Audience
- 一般
- Note (General)
- (主査) 教授 相沢 智康, 教授 芳賀 永, 教授 中村 公則生命科学院（ソフトマター専攻）
- DOI
- 10.14943/doctoral.k15675
- Persistent ID (NDL)
- info:ndljp/pid/13520731
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- Acquisition Basis
- 博士論文（自動収集）
- Date Accepted (W3CDTF)
- 2024-04-05T22:42:17+09:00
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Is Referenced By (URI)
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション
- Summary, etc.
- Mulberry leaves containα glucosidase inhibitors, which have hypoglycemic effects and are considered functional foods. However, few reports have covered the effects of mulberry leaf components on normal gut microbiota and gut metabolites. Herein, gut microbiota analysis and NMR based metabolomics were performed on the feces of mulberry leaf powder (MLP) treated mice to determine the effects of long term MLP consumption. Gut microbiota in the mouse were analyzed using 16S rRNA gene sequencing, and no significant differences were revealed in the diversity and community structure of the gut microbiota in the C57BL/6 mice with or without MLP supplementation. Thirty nine metabolites were identified via 1 H NMR analysis, and carbohydrates and amino acids were significantly ( p < 0.01 0.05) altered upon MLP treatment. In the MLP treated group, there was a marked increase and decrease in maltose and glucose concentrations, respectively, possibly due to the degradation inhibitory activity of oligosaccharides. After 5 weeks, all ami no acid concentrations decreased. Furthermore, despite clear fluctuations in fecal saccharide concentrations, short chain fatty acid production via intestinal bacterial metabolism was not strongly affected. This study provides the knowledge that MLP administration can alter the gut metabolites without affecting the normal gut microbiota, which is useful for considering MLP as a healthy food source.
- DOI
- 10.14943/doctoral.k15675
- Format (IMT)
- application/pdf
- Source
- Li_Gan.pdf （fulltext）
- Access Restrictions
- インターネット公開
- Is Referenced By (URI)
- HDL
- Data Provider (Database)
- 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
- Original Data Provider (Database)
- 北海道大学 : 北海道大学学術成果コレクション